About Co-Phenotrope In IBS

Co-phenotrope is an anti-diarrheal drug sometimes used in the treatment of your Irritable Bowel Syndrome.

This drug is generally used for short term use if your diarrhea is bad, but sometimes has the unwanted side effect of constipation if taken regularly.

When you are looking to purchase this medication, you may find it under the trade names of Lomotil, Diarphen and Tropergen.

The active ingredients are Atropine Sulfate and Diphenoxylate Hydrochloride 

Select A Topic:

  • Indications - find out what Co-Phenotrope is used for 
  • Side Effects - what are the potential harmful effects of this form of medication
  • The Adult Dose - how much should I be taking? If you need advice, you can find it here

Co-Phenotrope Picture

Co-phenotrope Indications

It is used in Irritable Bowel Syndrome (Unlicensed use in UK) and as an aid to rehydration in acute diarrhea and in chronic mild Ulcerative colitis too.

If symptoms don't settle always seek advice from your doctor.

Cautions With This Medicine

When considering this drug it is important to discuss with a health care professional to see if it is right for you. 

In particular, you should always seek medical advice if:

  • You are pregnant or breastfeeding your baby
  • You have any history of previous drug allergy
  • Are taking any medications
  • If you have any medical illnesses in particular heart, high blood pressure, , adrenal, thyroid, lung or liver disease 
  • Any symptoms of rectal bleeding, weight loss or persistent symptoms despite taking the drug
  • Any history of difficulty in passing urine as this medicine can exacerbate the problem or cause retention
  • If you have any nerve disorders such as myasthenia gravis or motor neuron disease
  • Any history of inflammatory bowel disease such as Crohn's or Ulcerative colitis
  • Any history of drug addiction

Potential Side Effects

This particular medication has many potential side effects including

  • Nausea and vomiting
  • Constipation
  • Abdominal cramps
  • Abdominal distension or bloating
  • Headache
  • Drowsiness
  • Low blood pressure
  • Dry mouth
  • Blurring of vision
  • Difficulty passing urine

May cause drowsiness - avoid driving or operating machinery in this situation. 

The Adult Dose

Initially 4 tablets, followed by 2 tablets every 6 hours until your diarrhea has come under control.

The Different Formulations Available

This medication comes in a variety of different formulations which makes for easy use.

It is available as tablets, chewable tablets, suspension, effervescent tablets, syrup and as an injection.

My View Of This Diarrhea Treatment

This drug is useful in diarrhea predominant Irritable Bowel Syndrome as it helps with both the frequency in which you are going to the toilet as well as the cramps.

It can also cause drowsiness (although seldom a problem), so for anyone with night time diarrhea, this can aid a more restful sleep as well as reducing the frequency that you have to go to the toilet.

As a short term aid in the management of your symptoms, it is very good, although I would personally recommend non-drug options in the longer term rather than the use of this drug alone.

References For This Drug:

1) A comparison of lomotil and imodium in acute non-specific diarrhoea.Jaffé G.J Int Med Res. 1977;5(3):195-8.

2) Acute effect of diphenoxylate with atropine (Lomotil) in patients with chronic diarrhea and fecal incontinence.Harford WV, Krejs GJ, Santa Ana CA, Fordtran JS.Gastroenterology. 1980 Mar;78(3):440-3.

3) Diphenoxylate hydrochloride (Lomotil) in the treatment of acute diarrhoea.Lustman F, Walters EG, Shroff NE, Akbar FA.Br J Clin Pract. 1987 Mar;41(3):648-51

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