Mebeverine Hydrochloride is an antispasmodic drug. It is also known as Colofac and is used in the treatment of Irritable Bowel Syndrome or IBS spasms.
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Used in the treatment of gastrointestinal disorders that cause smooth muscle spasm.
Main indication - IBS or the Irritable Bowel Syndrome
You should discuss with your doctor before taking if:
It should be avoided in those known to be allergic to the drug or have had a previous anaphylactic reaction to it.
It is available as tablets, capsules or as a liquid preparation.
Tablets: Adult and Child (over 10 years) 135 mg three times a day 20 minutes before food.
Capsules: 200 mg Modified Release two times a day 20 minutes before food
Liquid: As directed
The side effects of this drug include:
I've got to say I am not a great fan of Mebeverine.
Whilst it can help some sufferers, I have found the majority of people have already tried it before seeing me, with little improvement.
When you look at the evidence, the drug is well tolerated. However, definite improvement in IBS is debatable.
1) A systematic review of efficacy and tolerability of Mebeverine in irritable bowel syndrome.Darvish-Damavandi M, Nikfar S, Abdollahi M.World J Gastroenterol. 2010 Feb 7;16(5):547-53. Review.
2) Colofac alters small bowel motility in irritable bowel syndrome.Evans PR, Bak YT, Kellow JE.Aliment Pharmacol Ther. 1996 Oct;10(5):787-93.
3) A double-blind crossover comparison study of the safety and efficacy of Colofac sustained release in the treatment of irritable bowel syndrome.Van Outryve M, Mayeur S, Meeus MA, Rosillon D, Hendrickx B, Ceuppens M.J Clin Pharm Ther. 1995 Oct;20(5):277-82.