About Mebeverine Hydrochloride For IBS

Mebeverine Hydrochloride is an antispasmodic drug. It is also known as Colofac and is used in the treatment of Irritable Bowel Syndrome or IBS spasms.

Select A Topic:

  • Cautions - what precautions do you need to take. Find out whether you should be taking the drug or not
  • Contraindications - when should  you never take this medicine? Find the answer here
  • Availability - what formulations of this medication are there? Find out more here
  • Dosage - how many should I be taking? This section gives you the answer to your question
  • Side Effects - having problems with Mebeverine Hydrochloride? Find out common SE's
  • My View - take a look at my thoughts on taking this common medication for IBS

Mebeverine Hydrochloride Picture

Drug Indications

Used in the treatment of gastrointestinal disorders that cause smooth muscle spasm.

Main indication - IBS or the Irritable Bowel Syndrome

Medication Cautions

You should discuss with your doctor before taking if:

  • You are pregnant 
  • Breast feeding
  • Have a history of drug allergy
  • Have a history of weight loss, new change in bowel habit, bleeding when going to the bathroom or a loss of appetite
  • Any health problems or take any medicines
  • Any history of paralytic ileus

Contraindications To Mebeverine

It should be avoided in those known to be allergic to the drug or have had a previous anaphylactic reaction to it.

Drug Availability

It is available as tablets, capsules or as a liquid preparation.


Tablets: Adult and Child (over 10 years) 135 mg three times a day 20 minutes before food. 

Capsules: 200 mg Modified Release two times a day 20 minutes before food

Liquid: As directed

Side Effects

The side effects of this drug include:

  • Insomnia
  • Dizziness
  • Constipation
  • Headaches
  • Skin rashes

My View Of Mebeverine Hydrochloride

I've got to say I am not a great fan of Mebeverine.

Whilst it can help some sufferers, I have found the majority of people have already tried it before seeing me, with little improvement.

When you look at the evidence, the drug is well tolerated. However, definite improvement in IBS is debatable.


1) A systematic review of efficacy and tolerability of Mebeverine in irritable bowel syndrome.Darvish-Damavandi M, Nikfar S, Abdollahi M.World J Gastroenterol. 2010 Feb 7;16(5):547-53. Review.

2) Colofac alters small bowel motility in irritable bowel syndrome.Evans PR, Bak YT, Kellow JE.Aliment Pharmacol Ther. 1996 Oct;10(5):787-93.

3) A double-blind crossover comparison study of the safety and efficacy of Colofac sustained release in the treatment of irritable bowel syndrome.Van Outryve M, Mayeur S, Meeus MA, Rosillon D, Hendrickx B, Ceuppens M.J Clin Pharm Ther. 1995 Oct;20(5):277-82.

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