Alosetron drug information, a treatment for diarrhea associated with the irritable bowel syndrome.
It's a selective 5-HT3 receptor antagonist which blocks the action of serotonin in the intestine (most of the bodies serotonin is in the gut, with a smaller percentage in the brain).
It reduces diarrhea and abdominal pain associated with IBS-D in women.
Select A Topic:
Treatment in diarrhoea predominant Irritable Bowel Syndrome in women who have previously failed conventional treatment.
This drug is also known as Lotronex.
You should discuss with a health care practitioner if you:
NOTE: Serious gastrointestinal side-effects (Ischaemic colitis and perforation) can occur.
The drug is not licensed in the UK.
The main side effects are:
The dose is 1mg tablet twice a day with or without food
Treatment with Alosetron should be reserved for special cases where all other measures have been considered.
IBS Diarrhea in women is the only indication for this medication. It doesn't have a license in the UK, so my experience of this drug is limited.
It can be potentially hazardous as discussed, so it should only be reserved in cases where all else has failed.
1) Pharmacologic and complementary and alternative medicine therapies for irritable bowel syndrome. Chey WD, Maneerattaporn M, Saad R. Gut Liver. 2011 Sep;5(3):253-66. Epub 2011 Aug 18
2) The risk of ischaemic colitis in irritable bowel syndrome patients treated with serotonergic therapies. Lewis JH. Drug Saf. 2011 Jul 1;34(7):545-65. doi: 10.2165/11590690-000000000-00000. Review.
3) Quality of life in patients with irritable bowel syndrome. Mönnikes H. J Clin Gastroenterol. 2011 Aug;45 Suppl:S98-101. Review PLEASE NOTE: Whilst this website has taken every care to make sure the information is correct, I cannot accept any liability for any of the above information.
If any concerns, always read the drug manufacturers guidelines or consult a doctor for advice about this IBS drug.