Alosetron For IBS

Alosetron drug information, a treatment for diarrhea associated with the irritable bowel syndrome.

It's a selective 5-HT3 receptor antagonist which blocks the action of serotonin in the intestine (most of the bodies serotonin is in the gut, with a smaller percentage in the brain).

It reduces diarrhea and abdominal pain associated with IBS-D in women.

Alosetron Tablets

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  • Cautions - when should you take cautions with this medicine. I'll explain it for you
  • Side Effects - what side effects does it have and how important are these to know?
  • Adult Dose - what dose is used in the treatment of the irritable bowel syndrome?

Alosetron In IBS

Treatment in diarrhoea predominant Irritable Bowel Syndrome in women who have previously failed conventional treatment.

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Other Drug Names

This drug is also known as Lotronex.

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Cautions

You should discuss with a health care practitioner if you:

  • Have any history of bleeding from the back passage
  • A history of stroke, high blood pressure or heart disease
  • Any history of drug sensitivity
  • Taking other medications
  • Are pregnant or breastfeeding
  • Any history of liver disease

NOTE: Serious gastrointestinal side-effects (Ischaemic colitis and perforation) can occur.

The drug is not licensed in the UK.

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Side effects

The main side effects are:

  • Constipation
  • Haemorrhoids
  • Abdominal distension
  • Ischaemic colitis (bowel inflammation caused by lack of blood supply to the gut) and subsequent perforation of the bowel
  • Allergic reaction

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Adult dose

The dose is 1mg tablet twice a day with or without food

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My View

Treatment with Alosetron should be reserved for special cases where all other measures have been considered.

IBS Diarrhea in women is the only indication for this medication. It doesn't have a license in the UK, so my experience of this drug is limited.

It can be potentially hazardous as discussed, so it should only be reserved in cases where all else has failed.

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The References:

1) Pharmacologic and complementary and alternative medicine therapies for irritable bowel syndrome. Chey WD, Maneerattaporn M, Saad R. Gut Liver. 2011 Sep;5(3):253-66. Epub 2011 Aug 18

2) The risk of ischaemic colitis in irritable bowel syndrome patients treated with serotonergic therapies. Lewis JH. Drug Saf. 2011 Jul 1;34(7):545-65. doi: 10.2165/11590690-000000000-00000. Review.

3) Quality of life in patients with irritable bowel syndrome. Mönnikes H. J Clin Gastroenterol. 2011 Aug;45 Suppl:S98-101. Review PLEASE NOTE: Whilst this website has taken every care to make sure the information is correct, I cannot accept any liability for any of the above information.

If any concerns, always read the drug manufacturers guidelines or consult a doctor for advice about this IBS drug.

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